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Updated: Apr 25, 2026
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Identification of PANoptosis-Related Biomarkers in Head and Neck Squamous Cell Carcinoma
Yichao Xia1, Huiquan Lou1, Shengjie Shao1
1Department of Oral and Maxillofacial Surgery, Yunnan Provincial Key Laboratory of Clinical Virology, The First People's Hospital of Yunnan Province, Kunming University of Science and Technology Affiliated Hospital, Kunming, China.
Background:
The early detection and diagnosis of head and neck squamous cell carcinoma (HNSCC) pose significant challenges.
Objectives:
This study explores the diagnostic and prognostic role of PANoptosis-related genes (PANRGs) in HNSCC.
Methods:
In this study, machine learning was used to identify PANoptosis-related biomarkers in HNSCC, and a corresponding prognostic risk model was constructed.
Results:
This study identified ZBP1, RIPK1, FADD, and RNF31 as biomarkers for HNSCC, among which ZBP1, RIPK1, and RNF31 served as protective factors, while FADD functioned as a risk factor. Based on the median Risk Score of the biomarkers, the validation set was categorized into high-risk and low-risk groups. NOBOX, SOX14, GBX1, and NKX2-4 were identified as hub genes playing critical roles in distinguishing the high-risk and low-risk groups, and these hub genes were significantly negatively enriched in the PPAR signaling pathway. Furthermore, immune infiltration analysis revealed that the abundance of immune cells in the low-risk group was significantly higher than that in the high-risk group.
Conclusion:
This study identified four PANoptosis-related biomarkers in HNSCC, with ZBP1, RIPK1, and RNF31 as protective factors and FADD as a risk factor. These findings provide new references for improving the prognosis of HNSCC patients and developing novel therapeutic strategies.
