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Related Experiment Video

Updated: Apr 25, 2026

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation

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Published on: July 6, 2022

Autonomic Function in Fragile X Syndrome: A Systematic Review.

Sydni Weissgold¹, Sarah E A Eley¹, Damien Wright¹

¹Patrick Wild Centre, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.

Journal of Intellectual Disability Research : JIDR

|April 24, 2026

Summary

This summary is machine-generated.

Fragile X syndrome (FXS) is linked to autonomic hyperarousal, a key clinical feature across all ages. Further research is needed to connect this sympathetic nervous system overactivation to specific symptoms in FXS.

Keywords:

autonomic function electrodermal activity fragile X syndrome heart rate variability pupillometry

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Published on: June 6, 2025

Area of Science:

Neuroscience
Genetics
Developmental Biology

Background:

Fragile X syndrome (FXS) is a primary genetic cause of intellectual disability and autism spectrum disorder.
Individuals with FXS frequently exhibit anxiety and behavioral challenges, potentially linked to autonomic dysfunction.
Autonomic nervous system function in FXS requires systematic investigation.

Purpose of the Study:

To systematically review existing evidence on autonomic function in individuals with Fragile X syndrome.
To consolidate findings on physiological measures of autonomic activity in FXS.
To identify patterns and variations in autonomic function across the lifespan in FXS.

Main Methods:

Conducted an electronic literature search across major databases (Medline, Embase, PsycINFO, Web of Knowledge).
Included studies published before April 22, 2025, that physiologically measured autonomic function in FXS.
Utilized a preregistered search strategy focusing on the autonomic nervous system in FXS.

Main Results:

28 studies met inclusion criteria, analyzing individuals aged <1 to 71 years.
75% of studies reported significant differences in autonomic function metrics between groups.
Autonomic hyperarousal was observed in 86% of FXS participants, suggesting a consistent phenotype.

Conclusions:

Autonomic hyperarousal is a prevalent clinical phenotype in Fragile X syndrome across all age groups.
Further research should explore the link between sympathetic nervous system overactivation and clinical symptoms in FXS.
Methodological variations and sample demographics currently limit direct comparison of study findings.