Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

β-Cyclodextrin Inclusion Complexes of 20-Hydroxyecdysone Derivatives: Synthesis, NMR Characterization, and In Vitro/In Vivo Evaluation of Antioxidant, Hepatoprotective, and Antimicrobial Activities.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Terpenoid Phytosomes as Advanced Delivery Systems: Molecular Interactions, Pharmacological Potential, and Scalable Manufacturing Approaches.

International journal of molecular sciences·2026
Same author

Polymer Matrices for Reversible Thermogelling Hydrogels: Principles, Fabrication, and Drug Delivery Prospects.

Polymers·2026
Same author

State of the Art and Development Trends in Obtaining Fast-Dissolving Forms of Creatine Monohydrate.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation.

Pharmaceutics·2025
Same author

Phase-Inversion In Situ Systems: Problems and Prospects of Biomedical Application.

Pharmaceutics·2025
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
Same journal

Comparative Phytochemical Studies on the Aerial Parts of <i>Teucrium davaeanum</i> Coss. and <i>Teucrium zanonii</i> Pamp.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

14.4K

Solid-State Synthesis Based on Natural Leucomisine.

Sergazy Adekenov1, Asel Amanzhan1, Dmitriy Savchenko1

  • 1JSC «Research and Production Center «Phytochemistry», M. Gazaliev St., Building 4, Karaganda 100009, Kazakhstan.

Molecules (Basel, Switzerland)
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

This study enhances leucomisine

Keywords:
disodium glycyrrhizinateleucomisinesolid dispersionsolubility

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

31.3K

Related Experiment Videos

Last Updated: May 5, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

14.4K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

31.3K

Area of Science:

  • Pharmacology and Phytochemistry
  • Materials Science
  • Drug Delivery Systems

Background:

  • Leucomisine, a sesquiterpene γ-lactone from Artemisia leucodes, possesses valuable therapeutic properties.
  • Its pharmaceutical application is hindered by poor aqueous solubility and low bioavailability.
  • Developing strategies to improve leucomisine's solubility is crucial for its medicinal use.

Purpose of the Study:

  • To investigate the solid-state synthesis of leucomisine using disodium glycyrrhizinate as a carrier.
  • To evaluate the impact of different synthesis methods on leucomisine's aqueous solubility and dissolution rate.
  • To elucidate the mechanisms behind solubility enhancement.

Main Methods:

  • Solid-state synthesis of leucomisine-disodium glycyrrhizinate complexes via solvent removal, simple mixing, and mixture heating.
  • Physicochemical characterization using visible-range spectrophotometry, microcrystalloscopy, optical property analysis, and X-ray phase analysis.
  • Quantification of solubility and dissolution rate improvements.

Main Results:

  • Synthesized solid dispersions demonstrated a 7-19-fold increase in leucomisine solubility.
  • Dissolution rates were significantly enhanced, showing a 36-100-fold increase.
  • The "simple mixing" method yielded the most substantial improvements in dissolution.

Conclusions:

  • Solid-state synthesis effectively enhances leucomisine's aqueous solubility and dissolution rate.
  • Mechanisms include loss of crystallinity, micronization, carrier-mediated solubilization, and colloidal solution formation.
  • Disodium glycyrrhizinate is a promising carrier for improving leucomisine's bioavailability.