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Related Experiment Video

Updated: May 12, 2026

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
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Focused Ultrasound Ablation for Neurological Disorders.

Haiden S Berton1, Haden D Ray1, Nicole Silva1

  • 1Department of Neurosurgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

Biological Psychiatry
|May 10, 2026
PubMed
Summary
This summary is machine-generated.

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Focused ultrasound ablation (FUSA) offers a minimally invasive treatment for neurological disorders. Current research integrates mechanistic insights with clinical data to refine patient selection and expand FUSA applications.

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Imaging

Background:

  • Focused ultrasound (FUS) has evolved from early exploration to practical transcranial applications for neurological and neuropsychiatric conditions.
  • Technological advancements enable focused ultrasound ablation (FUSA) for creating thermal lesions and non-thermal or non-ablative interventions.
  • Magnetic resonance (MR) imaging and thermometry are crucial for guiding and monitoring FUS procedures.

Purpose of the Study:

  • To review the mechanistic principles of focused ultrasound ablation (FUSA).
  • To synthesize current clinical evidence for FUSA in neurological and neuropsychiatric disorders.
  • To identify priorities for improving patient selection, targeting, and expanding FUSA applications.

Main Methods:

  • Review of existing literature on focused ultrasound applications in neurology.
Keywords:
AblationEssential tremorFocused ultrasoundNeurological disordersParkinson’s disease

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  • Integration of mechanistic understanding with clinical trial data.
  • Analysis of the role of neuroimaging in FUSA procedures.

    • Main Results:

    • Focused ultrasound ablation (FUSA) is FDA-approved for essential tremor and Parkinson's disease, showing significant and lasting motor symptom improvement.
    • Ongoing clinical investigations explore FUSA for epilepsy, dystonia, and psychiatric disorders.
    • Neuroimaging techniques are vital for the successful application and assessment of FUSA therapies.

    Conclusions:

    • Focused ultrasound ablation (FUSA) demonstrates significant potential for treating a range of neurological and neuropsychiatric conditions.
    • Further research is needed to optimize patient selection and procedural targeting for broader FUSA implementation.
    • Integrating mechanistic insights with clinical evidence will drive the expansion of FUSA therapies.