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Updated: May 12, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Plasmonic Gold Prism Array for Digital Surface-Enhanced Raman Spectroscopy Sensing.

Peng Zheng1, Lintong Wu1, Ishan Barman2

  • 1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States.

The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
|May 11, 2026
PubMed
Summary
This summary is machine-generated.

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A new gold prism array enables digital surface-enhanced Raman spectroscopy (SERS) by leveraging signal fluctuations for femtomolar detection. This plasmonic substrate offers enhanced sensitivity for various analytical applications.

Area of Science:

  • Plasmonics
  • Spectroscopy
  • Nanomaterials

Background:

  • Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique limited by signal fluctuations due to dynamic molecule-metal interactions.
  • Quantitative SERS analysis at ultralow concentrations is compromised by these fluctuations.
  • Digital SERS offers a novel approach by utilizing signal stochasticity for enhanced detection limits.

Purpose of the Study:

  • To develop superior two-dimensional plasmonic substrates for routine digital SERS analysis.
  • To introduce and characterize a plasmonic gold prism array for digital SERS sensing.
  • To demonstrate femtomolar level detection using the gold prism array.

Main Methods:

  • Fabrication of a plasmonic gold prism array.
Keywords:
Digital SERSGold Prism ArrayPlasmonicsRaman SpectroscopySensing

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Last Updated: May 12, 2026

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  • Characterization of plasmonic properties, including scattering and surface features.
  • Utilizing digital SERS approach with a predefined signal threshold.
  • SERS measurements using 4-aminothiophenol as a model analyte.

    • Main Results:

    • The gold prism array exhibits strong scattering and nanoparticle-like surface features, providing plasmonic enhancement beyond vertex and edge modes.
    • SERS hotspots were predominantly observed at the center of the gold prisms, contrary to expectations.
    • Digital SERS sensing was successfully demonstrated at the femtomolar level.

    Conclusions:

    • The plasmonic gold prism array serves as a superior substrate for digital SERS.
    • This platform enables highly sensitive molecular detection, pushing the limits of current SERS capabilities.
    • The gold prism array holds significant potential for applications in diagnostics, environmental monitoring, and food safety.