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Hyperconjugation Effect in the Conformational Preference of Cyclohexene-Based β-Amino Acids

Jieun Lee1, Minseok Oh1, Seonho Shin1

  • 1Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

The Journal of Organic Chemistry
|May 15, 2026
PubMed
Summary

Two novel cyclic amino acids influence peptide helix formation. cis-2-Aminocyclohex-4-enecarboxylic acid (cis-4-ACHE) allows dual helical folding, while cis-2-aminocyclohex-3-enecarboxylic acid (cis-3-ACHE) favors a specific conformation due to electronic effects.

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