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Updated: May 19, 2026

Simultaneous Eye Tracking and Single-Neuron Recordings in Human Epilepsy Patients
Published on: June 17, 2019
Brain-wide information flow dynamics during novel visual processing in humans
Wushuang Huang1,2, Jianping Song1, Jingru Huangfu3
1Department of Neurosurgery, Epilepsy Research Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
None:
The human brain's capacity for visual information processing is essential for higher-order cognitive functions, including facial recognition and spatial navigation. However, the millisecond-scale dynamics of cortico-subcortical information flow during novel visual stimulation remain unclear. To investigate this, we conducted intracranial electroencephalography (iEEG) recordings in 22 patients with refractory epilepsy as they underwent a picture-viewing task. Our findings showed region-specific modulations in high-frequency broadband (HFB, 60-160 Hz) activity across multiple brain regions, such as the dorsal and ventral visual streams, the limbic system, and higher-order cortical areas. Initial activation followed a hierarchical, back-to-front propagation pattern, starting from the primary visual areas, progressing through the ventral and dorsal streams, and ultimately engaging high-order cortical and limbic structures. Extensive top-down connectivity from higher-order cortex to limbic areas further revealed their role in novel visual processing, providing a high-resolution spatiotemporal map of visual information flow across brain regions.
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