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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Lipid Catabolism01:25

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...

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Updated: May 19, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Published on: January 31, 2025

Lipid Metabolism and Oncogenesis.

Mirunalini Gobinath1, Pratik Phalke2, Parikshit Roychowdhury2

  • 1Department of Pharmacognosy & Phytopharmacy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, India.

Cancer Treatment and Research
|May 17, 2026
PubMed
Summary

Cancer cells alter lipid metabolism for growth and survival. Understanding these changes in lipid biosynthesis offers new therapeutic strategies for cancer treatment and overcoming resistance.

Keywords:
AngiogenesisCancer progressionMetastasisOxidative stressSphingolipidsSphingosineTumor microenvironment

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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

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Last Updated: May 19, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Area of Science:

  • Oncology
  • Cancer Biology
  • Metabolic Pathways

Background:

  • Cancer cells exhibit metabolic alterations supporting growth, survival, and metastasis.
  • Tumor microenvironment (TME) changes and immune modulation influence cancer progression.
  • Overexpression of enzymes like fatty acid (FA) synthase drives de novo lipid biosynthesis, promoting angiogenesis.

Purpose of the Study:

  • To provide a comprehensive overview of lipid metabolic pathways in cancer.
  • To explore the role of lipid metabolism in tumor progression and oncogenesis.
  • To highlight the potential of targeting lipid metabolism for novel cancer therapies.

Main Methods:

  • Review of current literature on lipid metabolism in cancer.
  • Analysis of molecular mechanisms underlying lipid biosynthesis and its oncogenic role.
  • Exploration of the connection between lipid metabolism, oxidative stress, and tumor formation.

Main Results:

  • Lipid metabolism is crucial for cancer cell growth, survival, and metastasis.
  • Abnormalities in cholesterol homeostasis, FA oxidation, and phospholipid metabolism contribute to cancer progression.
  • Sphingosine-1-phosphate plays a role in activating inflammatory signaling molecules in cancer.

Conclusions:

  • Understanding lipid metabolism in cancer development is key to discovering new therapeutic strategies.
  • Targeting lipid biosynthesis pathways may help overcome chemoresistance and immunotherapy resistance.
  • Lipid metabolism significantly contributes to oncogenesis and tumor cell formation.