Related Experiment Video
Updated: May 19, 2026
07:20
Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Lipid Metabolism and Oncogenesis
Mirunalini Gobinath1, Pratik Phalke2, Parikshit Roychowdhury2
1Department of Pharmacognosy & Phytopharmacy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, India.
Cancer Treatment and Research
|May 17, 2026
Summary
Cancer cells alter lipid metabolism for growth and survival. Understanding these changes in lipid biosynthesis offers new therapeutic strategies for cancer treatment and overcoming resistance.
Area of Science:
- Oncology
- Cancer Biology
- Metabolic Pathways
Background:
- Cancer cells exhibit metabolic alterations supporting growth, survival, and metastasis.
- Tumor microenvironment (TME) changes and immune modulation influence cancer progression.
- Overexpression of enzymes like fatty acid (FA) synthase drives de novo lipid biosynthesis, promoting angiogenesis.
Purpose of the Study:
- To provide a comprehensive overview of lipid metabolic pathways in cancer.
- To explore the role of lipid metabolism in tumor progression and oncogenesis.
- To highlight the potential of targeting lipid metabolism for novel cancer therapies.
Main Methods:
- Review of current literature on lipid metabolism in cancer.
- Analysis of molecular mechanisms underlying lipid biosynthesis and its oncogenic role.
- Exploration of the connection between lipid metabolism, oxidative stress, and tumor formation.
Main Results:
- Lipid metabolism is crucial for cancer cell growth, survival, and metastasis.
- Abnormalities in cholesterol homeostasis, FA oxidation, and phospholipid metabolism contribute to cancer progression.
- Sphingosine-1-phosphate plays a role in activating inflammatory signaling molecules in cancer.
Conclusions:
- Understanding lipid metabolism in cancer development is key to discovering new therapeutic strategies.
- Targeting lipid biosynthesis pathways may help overcome chemoresistance and immunotherapy resistance.
- Lipid metabolism significantly contributes to oncogenesis and tumor cell formation.
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