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Updated: May 19, 2026
Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
Published on: March 14, 2022
Transcriptomic profiling for identifying differentially expressed genes in aneurysm
G Shirley Lois1, Shanmugapriya Murugan1, Mohana Shanmugam Jaganathan1
1Department of Bioinformatics, Sri Ramachandra Faculty of Engineering and Technology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
None:
Aneurysm progression is associated with complex molecular alterations that are insufficiently studied at transcriptomics level. An aneurysm is characterized as a bulge or a weak spot in a blood artery's wall that causes the vessel to abnormally enlarge or balloon, exceeding 50% of its normal diameter. In the present study aneurysm RNA sequencing (RNA-Seq) dataset involving 14 samples, which include 7 controls and 7 treatments was selected for the analysis. Pathway analysis showed the involvement of key genes in major shifts within lipid metabolism pathways. The protein-protein interaction (PPI) network analysis using the STRING database identified key hub genes that were significantly differentially expressed, including LIPE, SREBF1, SCARB2, LPL, PNPLA2, UCP1, CIDEC, DGAT2, CIDEA and FABP4. These key gene-encoded proteins may be prominent drug targets for future interventions aimed at treating aneurysms.
