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Related Experiment Video

Updated: May 20, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
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Multi-potential laser-induced graphene fluidic paper-based array for in-flow differential analysis of phenolic

Ida Valeria Di Cristoforo1, Flavio Della Pelle2, Annalisa Scroccarello2

  • 1Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Campus "Aurelio Saliceti" Via R. Balzarini 1, Teramo, 64100, Italy; University School for Advanced Studies IUSS Pavia, Piazza Della Vittoria, 15, Pavia, 27100, Italy.

Talanta
|May 18, 2026
PubMed
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This study introduces a novel paper-based microfluidic device with laser-induced graphene (LIG) sensors for analyzing phenolic compounds in food. The device enables rapid, quantitative classification of food based on electrochemical reactivity patterns.

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Electrochemistry

Background:

  • Integrating laser-induced sensing with paper microfluidics is challenging.
  • Laser-induced graphene (LIG) offers promising sensing capabilities.
  • Paper-based analytical devices (PADs) are cost-effective and portable.

Purpose of the Study:

  • To develop an integrated, pump-free paper-based microfluidic device with LIG sensors.
  • To enable quantitative determination and classification of phenolic compounds in food.
  • To optimize CO2 laser parameters for enhanced LIG sensor performance.

Main Methods:

  • Fabrication of a multichannel-LIG fluidic paper-based analytical device (fLIG-PAD) using a CO2 laser plotter.
  • Optimization of CO2 laser parameters for LIG film morphology and charge transfer.
Keywords:
CO(2) laserContinuous paper-fluidicGrapheneMultiplexed systemPaper-based deviceSensor array

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  • Electrochemical analysis of phenolic compounds using flow amperometry.
  • Correlation of fLIG-PAD results with High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS/MS).

    • Main Results:

    • The fLIG-PAD successfully differentiated phenolic compounds into four reactivity levels.
    • Quantitative analysis of phenolic content in food matrices with high accuracy (R2 ≥ 0.990).
    • Simultaneous, continuous measurements with fast signal recovery (≤570 s).
    • Food samples were classified based on phenolic profiles, correlating well with HPLC-MS/MS (r = 0.97).

    Conclusions:

    • The developed fLIG-PAD is a powerful tool for simultaneous analysis and classification of phenolic compounds in food.
    • This technology offers a portable, cost-effective solution for food safety and quality assessment.
    • The study demonstrates the potential of laser-induced graphene in advanced paper-based analytical devices.