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Gold Redox Catalysis Enabled by Cyclic Diacyl Peroxides for Homocoupling and Cross-Coupling of Terminal Alkynes
Haowei Gao1, Jiale Yan1, Chao Zeng1
1School of Chemistry and Chemical Engineering, School of Science (Shenzhen), Harbin Institute of Technology, Harbin, China.
Abstract:
Conjugated 1,3-diynes are valuable scaffolds, yet their selective assembly via cross-coupling of terminal alkynes remains challenging. In this study, we report a gold redox catalytic system employing cyclic diacyl peroxides as dual-function oxidants that enable both homocoupling and cross-coupling of terminal alkynes without exogenous ligands. This operationally simple protocol proceeds under mild conditions, exhibits broad substrate scope, and delivers symmetrical and unsymmetrical 1,3-diynes in moderate to good yields. The tether-guided redox platform facilitates efficient Au(I)/Au(III) redox cycling, offering a previously unrecognized catalytic paradigm to ligand-free gold catalysis for selective C(sp)─C(sp) bond formation.
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