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Updated: May 28, 2026
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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
Polymeric Nanogels for Skin Applications
Sara Silva1, Manuela Machado1, Eduardo M Costa1
1Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Gels (Basel, Switzerland)
|May 27, 2026
Summary
Polymeric nanogels offer advanced topical delivery for chronic inflammatory skin diseases like psoriasis and atopic dermatitis. These nanocarriers enhance drug penetration and therapeutic efficacy, overcoming limitations of conventional treatments.
Area of Science:
- Biomaterials Science
- Dermatology
- Nanotechnology
Background:
- Chronic inflammatory skin diseases, such as psoriasis and atopic dermatitis, impact millions globally, causing significant physical, psychological, and economic burdens.
- Conventional topical therapies often exhibit poor skin penetration, rapid clearance, and undesirable side effects, leading to suboptimal patient adherence.
- Polymeric nanogels represent a novel drug delivery platform with dimensions of 10-200 nm, designed to overcome these therapeutic challenges.
Purpose of the Study:
- To review nanogel synthesis methods specifically optimized for treating skin inflammatory diseases.
- To explore the potential of biopolymer-based nanogels, including chitosan and hyaluronic acid, for enhanced therapeutic action.
- To discuss translation challenges and emerging opportunities for nanogel-based therapies in dermatology.
Main Methods:
- Review of scientific literature on polymeric nanogel synthesis for skin applications.
- Analysis of nanogel properties such as high water content, tunable porosity, biocompatibility, and deformability.
- Examination of stimulus-responsive nanogel architectures for targeted drug delivery.
Main Results:
- Nanogels demonstrate enhanced skin penetration and targeted therapeutic action due to their unique physicochemical properties.
- Biopolymer-based nanogels, particularly those using chitosan and hyaluronic acid, show promise for multifunctional capacities and bioactivities.
- Advanced nanogel architectures can be designed for specific therapeutic needs in inflammatory skin conditions.
Conclusions:
- Polymeric nanogels are a promising advanced platform for topical treatment of chronic inflammatory skin diseases.
- Further research and development are needed to address manufacturing scalability, long-term safety, and regulatory hurdles for clinical translation.
- Emerging opportunities include personalized medicine approaches and smart microneedle-integrated systems for adaptive nanogel therapy.
