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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Polymeric Nanogels for Skin Applications.

Sara Silva1, Manuela Machado1, Eduardo M Costa1

  • 1Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

Gels (Basel, Switzerland)
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Polymeric nanogels offer advanced topical delivery for chronic inflammatory skin diseases like psoriasis and atopic dermatitis. These nanocarriers enhance drug penetration and therapeutic efficacy, overcoming limitations of conventional treatments.

Keywords:
atopic dermatitisimmunomodulationnanozymespolymeric nanogelspsoriasisskin inflammatory diseasesstimuli-responsivetransdermal drug delivery

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Nanotechnology

Background:

  • Chronic inflammatory skin diseases, such as psoriasis and atopic dermatitis, impact millions globally, causing significant physical, psychological, and economic burdens.
  • Conventional topical therapies often exhibit poor skin penetration, rapid clearance, and undesirable side effects, leading to suboptimal patient adherence.
  • Polymeric nanogels represent a novel drug delivery platform with dimensions of 10-200 nm, designed to overcome these therapeutic challenges.

Purpose of the Study:

  • To review nanogel synthesis methods specifically optimized for treating skin inflammatory diseases.
  • To explore the potential of biopolymer-based nanogels, including chitosan and hyaluronic acid, for enhanced therapeutic action.
  • To discuss translation challenges and emerging opportunities for nanogel-based therapies in dermatology.

Main Methods:

  • Review of scientific literature on polymeric nanogel synthesis for skin applications.
  • Analysis of nanogel properties such as high water content, tunable porosity, biocompatibility, and deformability.
  • Examination of stimulus-responsive nanogel architectures for targeted drug delivery.

Main Results:

  • Nanogels demonstrate enhanced skin penetration and targeted therapeutic action due to their unique physicochemical properties.
  • Biopolymer-based nanogels, particularly those using chitosan and hyaluronic acid, show promise for multifunctional capacities and bioactivities.
  • Advanced nanogel architectures can be designed for specific therapeutic needs in inflammatory skin conditions.

Conclusions:

  • Polymeric nanogels are a promising advanced platform for topical treatment of chronic inflammatory skin diseases.
  • Further research and development are needed to address manufacturing scalability, long-term safety, and regulatory hurdles for clinical translation.
  • Emerging opportunities include personalized medicine approaches and smart microneedle-integrated systems for adaptive nanogel therapy.