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Updated: May 28, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Direct deaminative functionalization
Zhangkai Cui1, Hongjian Lu1,2
1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China. hongjianlu@nju.edu.cn.
Abstract:
Amines, ubiquitous both in nature and synthetic molecules, have long been regarded as static end points in organic synthesis. Unlocking their potential as distinct reactive handles for molecular editing represents a profound shift in synthetic logic. To address this limitation, direct deaminative functionalization has emerged as a transformative solution. This step-economic strategy revolutionizes synthetic design by converting readily available C-N bonds into valuable C-C and C-heteroatom linkages. Herein, we move beyond the fragmented landscape of isolated reports to establish a unified bond-centric framework. By organizing advances according to the specific bond formed, this Review provides a comprehensive and systematic overview of this rapidly expanding field. We highlight the strategic utility of distinct activation platforms in late-stage functionalization, illustrating their value as practical tools for molecular diversification.
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