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Updated: May 29, 2026

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)
Published on: June 28, 2017
Imaging quantum chemistry in action with quantum attomicroscopy
Nikolay V Golubev1, Mohammed Th Hassan2
1Department of Physics, University of Arizona, Tucson, AZ, USA. ngolubev@arizona.edu.
Abstract:
Understanding how quantum electron and nuclei motions drive biomolecular reactions is a foundational challenge in quantum chemistry and biology. While ultrafast charge migration in DNA is theorized to influence genome stability and signaling, real-time observation remains elusive. Here, we report a theoretical study employing high-level ab initio simulations to reveal attosecond charge dynamics and electronic coherences within canonical DNA base pairs. Experimentally, we propose the "quantum attomicroscope" (Q-attomicroscope)-a conceptual instrument providing attosecond temporal and sub-angstrom spatial resolution. By bridging theory and instrumentation, this work outlines a pathway for laser-mediated DNA manipulation with transformative implications for chemical reactivity and personalized medicine.
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