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Updated: Jun 9, 2026
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
4-[4-(4-Chloro-1,2,5-thia-diazol-3-yl)phen-yl]morpholine
Paul R Palme1, Richard Goddard2, Adrian Richter1
1Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.
Abstract:
The title compound, C12H12ClN3OS, was prepared using a Suzuki-Miyaura cross-coupling reaction. The compound was found to crystallize in the ortho-rhom-bic system (space group Pbca, Z = 8). The crystal structure was refined with non-spherical atomic form factors using Hirshfeld atom refinement. The mean planes through the thia-diazole ring and the benzene ring are inclined at an angle of 36.83 (2)°. The morpholine ring adopts a chair conformation with a markedly pyramidal bonding situation at the N atom. The crystal packing is dense, with a packing index of 75%.
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