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Multidimensional Voice Profiles of Children With and Without Vitamin D Deficiency: A Pilot Cross-Sectional
Buket Kılıçaslan Hersekli1, Namık Yücel Birol2, Ferhat Alkan3
1Buket Kılıçaslan Hersekli Private Pediatric Clinic, Adana, Türkiye.
Summary
Vitamin D deficiency in children aged 3-12 did not show significant differences in voice quality, acoustic, or aerodynamic measures in this pilot study. Low vitamin D status appears unlikely to cause overt voice problems detectable by standard assessments.
Area of Science:
- Pediatric Voice Science
- Nutritional Immunology
- Clinical Otolaryngology
Background:
- Vitamin D plays a crucial role in immune function and overall health.
- Emerging research suggests potential links between vitamin D status and various physiological functions, including vocal health.
- Understanding the impact of vitamin D deficiency on pediatric voice is essential for comprehensive child health assessment.
Purpose of the Study:
- To compare multidimensional voice profiles in children with and without vitamin D deficiency.
- To investigate associations between low vitamin D status and perceptual, parent-reported, acoustic, and aerodynamic voice characteristics in children.
- To establish baseline data for future research on vitamin D and pediatric voice.
Main Methods:
- A cross-sectional comparative study of 47 children (aged 3-12 years) classified by serum 25-hydroxyvitamin D [25(OH)D] levels.
- Voice assessment included the Turkish Pediatric Voice Handicap Index (pVHI), GRBAS scale, acoustic analysis (fundamental frequency, jitter, shimmer, HNR, CPPS), and aerodynamic measures (MPT, s/z ratio).
- Between-group comparisons utilized independent-samples t tests or Mann-Whitney U tests, with age- and sex-adjusted sensitivity analyses.
Main Results:
- No statistically significant differences were found between children with and without vitamin D deficiency for GRBAS parameters, pVHI scores, or most acoustic/aerodynamic measures.
- Age- and sex-adjusted analyses confirmed the lack of significant differences in acoustic and aerodynamic outcomes.
- An isolated adjusted difference was noted in the pVHI Emotional subscale, warranting further investigation.
Conclusions:
- Vitamin D deficiency was not associated with significant differences in primary multidimensional voice measures in this pediatric pilot sample.
- Current findings suggest that low vitamin D status may not lead to overt voice impairment detectable by conventional assessments in children.
- Larger, age-stratified studies employing more sensitive voice measures are recommended to explore potential subtle effects.
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