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Identification of the Novel HLA-A*32:181 Allele Using Polymerase Chain Reaction Sequence-Based Typing.
Yizhen He1, Lina Dong1, Fang Wang1
1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
HLA
|June 10, 2026
Summary
A novel Human Leukocyte Antigen (HLA) allele, HLA-A*32:181, has been identified. It differs from the common HLA-A*32:01:01:01 by a single nucleotide substitution in exon 3.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
- Polymorphisms in HLA genes are crucial for transplantation and disease association studies.
Purpose of the Study:
- To report the characterization of a newly identified HLA-A allele.
Main Methods:
- Sequence analysis of the HLA-A gene.
Main Results:
- A novel allele, HLA-A*32:181, was identified.
- This allele differs from HLA-A*32:01:01:01 by a single nucleotide substitution (C>T) at position 500 in exon 3.
Conclusions:
- The discovery of HLA-A*32:181 expands the known HLA-A allele repertoire.
- This finding contributes to the understanding of HLA polymorphism.
