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Related Experiment Video

Updated: Jun 13, 2026

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
06:14

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Published on: January 7, 2019

Injectable Short Nanofiber Fragments Enable Conformal Fibrous Scaffolds for Tissue Engineering on Complex Surfaces.

Iruthayapandi Selestin Raja1, Hee Jeong Jang2, Elif Beyza Demiray1

  • 1Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea.

Macromolecular Rapid Communications
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Short nanofiber fragments (SNFs) create conformal scaffolds on complex surfaces, enhancing tissue engineering. These biocompatible SNFs support cell growth, showing promise for regenerative medicine applications.

Keywords:
cell proliferationelectrospun nanofiber matsshort nanofiber fragmentstissue engineering

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Related Experiment Videos

Last Updated: Jun 13, 2026

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
06:14

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Published on: January 7, 2019

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Polymeric nanofibers are used in drug delivery but have limited use as tissue engineering scaffolds.
  • Developing materials for complex substrates is crucial for advanced tissue engineering.

Purpose of the Study:

  • To develop short nanofiber fragments (SNFs) for conformal scaffold formation on diverse substrates.
  • To evaluate the cytocompatibility and cell proliferation on SNF-coated surfaces.

Main Methods:

  • Poly(D-lactide)/gelatin (PG) nanofiber mats were fragmented into SNFs using probe sonication.
  • SNFs were deposited onto impermeable and porous substrates via drop casting.
  • Scanning electron microscopy and in vitro cell culture (nHDF, MC3T3-E1) were used for evaluation.

Main Results:

  • SNFs formed uniform, interconnected fibrous networks on both impermeable and porous substrates, infiltrating porous structures.
  • Surface wettability increased significantly after fragmentation (11.5° reduction in water contact angle).
  • PG3 SNF-coated substrates showed excellent cytocompatibility and supported time-dependent cell proliferation comparable to intact nanofiber mats.

Conclusions:

  • SNFs enable conformal scaffold formation on complex surfaces, overcoming limitations of direct electrospinning.
  • This approach offers a promising strategy for advanced tissue engineering applications requiring intricate scaffold architectures.
  • SNFs demonstrate excellent biocompatibility and support cell growth, making them suitable for regenerative medicine.