Near-infrared light-driven plasmonic catalysis empowers tumor nanotherapy

Area of Science:

• Biomedical Materials Science
• Nanotechnology
• Cancer Therapy

Background:

• Life processes depend on efficient catalysis, with precise regulation offering tumor therapy potential.
• Near-infrared (NIR) light is ideal for controllable biocatalysis due to tissue permeability.
• Plasmonic nanomaterials efficiently convert NIR light to heat, crucial for catalytic processes.

Purpose of the Study:

• To review NIR light-driven plasmonic catalysis therapy (PCT) for tumor treatment.
• To explore mechanisms and biological effects of PCT in the tumor microenvironment.
• To analyze challenges and provide design principles for plasmonic nanobiomaterials.

Main Methods:

• Review of fundamental principles of plasmonic catalysis and materials.
• Focus on NIR light-driven PCT mechanisms and biological effects.
• Analysis of endogenous reactant consumption and therapeutic product formation.

Main Results:

• Plasmonic nanomaterials efficiently utilize NIR light for photothermal conversion.
• PCT can overcome tumor hypoxia and antioxidation by amplifying oxidative stress.
• PCT reshapes tumor metabolism, offering a new therapeutic strategy.

Conclusions:

• NIR light-driven PCT is a promising strategy for precise and efficient tumor therapy.
• Understanding PCT mechanisms is key to overcoming tumor microenvironment limitations.
• Further development of plasmonic nanobiomaterials is needed for advanced PCT applications.