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Updated: Jun 18, 2026
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[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photocatalyst-free EDA-complex-enabled radical difluoroalkylation/cyclization for access to difluoroalkylated
Bei Liu1, Yongmei Xiao1, Lili Wang1
1School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China. mxyy9510@126.com.
Abstract:
A photocatalyst-free and electron donor-acceptor (EDA)-complex-enabled radical difluoroalkylation/cyclization of unactivated alkenes with bromodifluoroacetamides has been developed for the efficient synthesis of difluoroalkyl-containing polycyclic coumarin derivatives, affording a total of 32 target compounds. In this transformation, persulfates act as electron donors and bromodifluoroacetamides serve as electron acceptors to generate an EDA complex, enabling visible-light-induced radical processes without the need for external photocatalysts. This method features mild reaction conditions, operational simplicity, metal-free nature, and broad functional group tolerance.
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