Automated dual-camera DMD system for stereo optical sectioning imaging

We present a compact, automated, stereo-optical-sectioning imaging system for clinical assessment of the anterior segment, using a digital micromirror device (DMD) as a spatial light modulator. The platform synchronizes two CMOS cameras with the DMD, which projects programmable slit beams to produce depth-resolved cross-sectional views of the anterior eye. By adjusting the micromirror activation time, the system can also extend the dynamic range of the acquired images, accommodating both dim (e.g., the cornea) and highly reflective regions (i.e., the iris). In a pilot study, the prototype instrument produced high-contrast images from eyes with corneal disorders, including scars, opacities, and foreign bodies. In addition, it enables the visualization of the corneal stromal nerves. The combination of a compact design, automated acquisition in 3.5 seconds, and its depth-resolved cross-sectional view and 3D representation suggests strong potential for routine, comprehensive digital imaging of the entire anterior segment. This approach could eventually serve as an alternative to conventional slit-lamp examinations in regular clinical settings.