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Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Congenital and Developmental
Mary Ann R Abacan1, Kathryn R Baltazar-Braganza2,3, Ian Theodore G Cabaluna4,5
1Division of Clinical and Metabolic Genetics, Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Acta Medica Philippina
|July 1, 2026
Summary
Philippine clinical practice guidelines recommend screening for congenital and developmental disorders in children. Recommendations cover conditions like critical congenital heart disease and G6PD deficiency, while advising against routine screening for others.
Area of Science:
- Pediatrics
- Clinical Genetics
- Public Health
Background:
- Early detection of congenital and developmental disorders is crucial to prevent severe complications like disability and death.
- The Philippines developed clinical practice guidelines (CPG) to standardize screening for these conditions in healthy neonates and children.
Purpose of the Study:
- To establish evidence-based recommendations for screening congenital and developmental disorders in apparently healthy Filipino children.
- To guide healthcare professionals in the Philippines on the appropriate screening protocols.
Main Methods:
- Adoption of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
- Formulation of 15 priority clinical questions by a multidisciplinary steering committee.
- Systematic evidence review, appraisal, and consensus-based recommendation development by a multisectoral panel.
Main Results:
- Twenty (20) recommendations were established for 15 prioritized screening questions.
- Recommendations support screening for critical congenital heart disease, thalassemia, Glucose-6-phosphate dehydrogenase (G6PD) deficiency, developmental delay, and autism spectrum disorder.
- Routine screening was not recommended for several inborn errors of metabolism and other genetic conditions.
Conclusions:
- Screening recommendations are based on evidence, disease burden, cost-effectiveness, and population applicability.
- The CPG aims to inform health policies but should be considered alongside existing practices for improving Filipino health outcomes.
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