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FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Prenatal Disorders.

Maria Julieta Corazon V Germar¹, Lia M Palileo-Villanueva¹, Sherri Ann L Suplido²

¹College of Medicine, University of the Philippines Manila, Manila, Philippines.

Acta Medica Philippina

|July 1, 2026

Summary

This guideline offers 11 evidence-based recommendations for prenatal screening in the Philippines to reduce neonatal deaths. It supports the Universal Health Care Act by improving maternal and infant health outcomes through accessible screening services.

Keywords:

antenatal care maternal health neonatal health prenatal clinical practice guidelines screening

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Published on: March 6, 2019

Area of Science:

Obstetrics and Gynecology
Public Health
Evidence-Based Medicine

Background:

Prenatal conditions are a significant cause of neonatal mortality in the Philippines, contributing to 14% of deaths in children under five.
The Philippine Guidelines on Periodic Health Examination (PHEX) aim to enhance the quality, accessibility, and affordability of screening services, aligning with the Universal Health Care Act.

Purpose of the Study:

To establish evidence-based recommendations for screening asymptomatic pregnant Filipino women for prenatal disorders.
To provide healthcare professionals, patients, and policymakers with tools for informed, evidence-based decision-making in prenatal care.

Main Methods:

The guideline development followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and the Evidence-to-Decision (EtD) framework.
Systematic literature reviews of local and international guidelines were conducted, with de novo reviews performed as needed.
A multisectoral consensus panel reviewed evidence on benefits, harms, cost-effectiveness, patient values, acceptability, feasibility, and equity.

Main Results:

Eleven recommendations were developed for screening strategies to improve maternal and neonatal health outcomes.
Recommendations cover screening for maternal thyroid disease, gestational diabetes mellitus, group B Streptococcus infection, fetal aneuploidy, preeclampsia risk, iron deficiency anemia, and undernutrition.
Specific screening methods include cervical length measurements, and first and second-trimester ultrasounds.

Conclusions:

The guideline provides 11 evidence-based recommendations tailored for the Philippine context, developed with stakeholder involvement.
These recommendations are intended to guide prenatal screening practices until new evidence necessitates updates.
The guideline is scheduled for review and potential update within three years.