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Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
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Related Experiment Video

Updated: Jul 4, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Sarcoidosis].

Maria Stilling-Vinther1, Lone Salomonsen1, Alexandra Wimmer-Aune2

  • 1Afdeling for Led-, Ryg- og Bindevævssygdomme, Aalborg Universitetshospital.

Ugeskrift for Laeger
|July 3, 2026
PubMed
Summary

Sarcoidosis is a granulomatous disease affecting multiple organs, primarily the lungs. Methotrexate may be a first-line therapy for long-term treatment when immunosuppression is needed.

Related Experiment Videos

Last Updated: Jul 4, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Pulmonology
  • Immunology
  • Rheumatology

Background:

  • Sarcoidosis is a multisystem granulomatous disease with >90% lung involvement.
  • Extrapulmonary manifestations frequently affect skin, eyes, lymph nodes, and can involve heart, kidneys, and nervous system.
  • Management requires multidisciplinary collaboration due to complexity.

Purpose of the Study:

  • To review the evaluation and treatment of sarcoidosis.
  • To highlight key imaging modalities for cardiac sarcoidosis.
  • To identify potential first-line therapies for long-term management.

Main Methods:

  • Review of current literature on sarcoidosis evaluation and treatment.
  • Emphasis on imaging techniques like MRI and PET/CT for cardiac sarcoidosis.
  • Analysis of therapeutic options, including immunosuppressive agents.

Main Results:

  • Cardiac sarcoidosis evaluation relies on MRI and PET/CT with prolonged fasting.
  • Many patients do not require immunosuppressive therapy.
  • Methotrexate identified as a potential first-line therapy for long-term treatment.

Conclusions:

  • Sarcoidosis management is complex and organ-specific.
  • Advanced imaging is crucial for diagnosing cardiac involvement.
  • Methotrexate offers a viable first-line option for sustained immunosuppression in sarcoidosis.