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Updated: Jul 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Solvent-free synthesis and low-temperature crystal structure of pheno-quinone (the 1:2 p-benzo-quinone-phenol
A Timothy Royappa1, Jake A Tan1, Dean H Johnston2
1Department of Chemistry University of West Florida, 11000 University Parkway Pensacola FL 32514 USA.
Abstract:
A novel solvent-free synthesis of pheno-quinone (the common name for the hydrogen-bonded 1:2 p-benzo-quinone-phenol complex, C6H4O2·2C6H6O) is reported. This 'green' method produces X-ray quality cocrystals of pheno-quinone as red needles within minutes. A newly redetermined and greatly improved low-temperature (100 K) crystal structure is reported. A time-dependent density functional theory examination of the charge-transfer excitation in pheno-quinone accounts for the red color of this hydrogen-bonded complex.
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