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Published on: November 8, 2024
Fentanyl Overdose Harm Reduction Intervention: A Pretest-Posttest Study Among High School Students in Southern
Neeraj Wadhwa1, Anna Nelson2, Daniel Handysides2
1Los Angeles County Department of Public Health, CA, USA.
Health Promotion Practice
|July 8, 2026
Summary
Harm reduction videos significantly improved adolescent knowledge and attitudes regarding fentanyl and opioid overdose risks. This pilot study highlights the potential of educational interventions in preventing adolescent substance use and overdose deaths.
Area of Science:
- Public Health
- Adolescent Health
- Substance Use Prevention
Background:
- Fentanyl is a potent synthetic opioid driving the U.S. overdose epidemic, posing significant risks to adolescents.
- Illicit fentanyl use in Los Angeles County has sharply increased mortality rates.
- Adolescents are particularly vulnerable to the rapid health deterioration caused by uncontrolled illicit opioids.
Purpose of the Study:
- To evaluate the effectiveness of two harm reduction videos in improving knowledge and attitudes among high school students.
- To assess the impact of educational interventions on substance use behaviors in adolescents.
- To inform public health strategies for opioid overdose prevention.
Main Methods:
- A pre-post design pilot study involving 76 high school students.
- Administration of pre- and post-tests to measure changes in knowledge and attitudes.
- Wilcoxon Signed Rank tests used for statistical analysis with SPSS 29.0.
Main Results:
- Statistically significant improvements in knowledge and attitudes were observed post-intervention and at 3-month follow-up.
- No significant decline in overdose knowledge retention was noted between post-test and follow-up.
- The study suggests educational interventions can positively influence adolescent perceptions of opioid risks.
Conclusions:
- Harm reduction videos are effective educational tools for improving adolescent knowledge and attitudes towards opioid risks.
- Community collaborations and accessible harm reduction resources are crucial for effective substance use prevention.
- Large-scale adoption of feasible educational interventions is recommended to combat the adolescent opioid overdose crisis.
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