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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jul 10, 2026

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

Tumor Metastasis in the Microcirculation.

Bingmei M Fu1

  • 1Department of Biomedical Engineering, The City College of the City University of New York, New York, NY, USA. fu@ccny.cuny.edu.

Advances in Experimental Medicine and Biology
|July 8, 2026
PubMed
Summary
This summary is machine-generated.

Understanding tumor cell metastasis is crucial for cancer treatment. This research explores how blood flow, vessel structure, and cell interactions influence cancer spread, offering new therapeutic targets.

Keywords:
Cell adhesion moleculesCirculating tumor cellsGlycocalyxIn vivo and in vitro modelsIntegrin signalingMicrovessel permeability and tumor metastasisTumor cell adhesion and transmigration across endothelium

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Last Updated: Jul 10, 2026

Lung Tumor Cell Recruitment Assay
04:28

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Published on: February 26, 2019

Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
05:49

Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle

Published on: April 27, 2021

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

Area of Science:

  • Oncology
  • Biophysics
  • Cell Biology

Background:

  • Tumor cell metastasis via blood circulation causes ~90% of cancer mortality.
  • Key steps include intravasation, arrest, adhesion, and extravasation at microvessel walls.
  • Endothelial cells and their surface glycocalyx regulate microvascular transport and tumor cell interactions.

Purpose of the Study:

  • To review advances in understanding tumor cell metastasis in microcirculation.
  • To highlight the roles of endothelial integrity, hydrodynamic factors, and microvascular geometry.
  • To present new findings on glycocalyx and a 3D microchannel model for metastasis.

Main Methods:

  • In vivo animal studies.
  • In vitro cell culture studies.
  • Development of a novel 3D-microchannel model.

Main Results:

  • Endothelial integrity, hydrodynamic forces, microvascular geometry, adhesion molecules, and extracellular matrix significantly impact metastasis.
  • The glycocalyx on tumor cells plays a role in metastasis.
  • The 3D microchannel model provides new insights into metastasis in microcirculation.

Conclusions:

  • Understanding microcirculatory dynamics and cellular interactions is key to developing anti-metastasis therapies.
  • The glycocalyx and microvascular environment are critical factors in tumor cell extravasation.
  • Advanced models are essential for studying complex metastatic processes.