Related Experiment Video
Updated: Jul 13, 2026
10:21
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Epigenetic Targeting in Myeloid Malignancies.
1Universidade Católica Portuguesa, Faculdade de Medicina, Sintra, Portugal. bacardoso@ucp.pt.
Advances in Experimental Medicine and Biology
|July 11, 2026
Summary
Epigenetic drugs targeting DNA methylation and histone modifications offer reversible treatments for myeloid malignancies. These therapies are advancing the clinical landscape for these cancers.
Area of Science:
- Oncology
- Pharmacology
- Epigenetics
Background:
- Epigenetic deregulation is a key feature in myeloid malignancies, influencing disease development and treatment outcomes.
- Epigenetic modifications are reversible, presenting unique opportunities for targeted drug development.
Purpose of the Study:
- To provide a comprehensive overview of current epigenetic drugs in preclinical and clinical development for myeloid malignancies.
- To detail the mechanisms of action and translational data for key epigenetic drug classes.
Main Methods:
- Review of preclinical and clinical data for epigenetic drugs.
- Focus on agents targeting histone deacetylases (HDACs), DNA methyltransferases (DNMTs), histone methyltransferases (HMTs), histone demethylases (HDMs), BET proteins, and mutant IDH1/2 enzymes.
Main Results:
- Summary of the current landscape of epigenetic therapies for myeloid malignancies.
- Highlighting the translational progress and clinical impact of these agents.
Conclusions:
- Epigenetic therapies are a rapidly evolving area in treating myeloid malignancies.
- These reversible treatments are significantly reshaping the clinical management of these hematological cancers.
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