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Updated: Jul 13, 2026

Revealing the Ferroptotic Phenotype of Medulloblastoma
Published on: March 15, 2024
Fueling Death: The Metabolic Control of Ferroptosis
Giovanna Carrà1,2,3, Alfonso Scalera4,5, Isaia Barbieri4,5
1San Luigi Gonzaga Hospital, Orbassano, Italy. giovanna.carra@uniupo.it.
None:
Ferroptosis is a metabolically regulated, iron-dependent form of cell death driven by lipid peroxidation. This chapter dissects the core metabolic circuits that converge to determine ferroptotic susceptibility and explores the interplay between ferroptosis and other cell death programs, highlighting its physiological roles in development, immunity, and aging, and examines its dual function in disease. Emerging pharmacological strategies to modulate ferroptosis in cancer and degenerative conditions are discussed. By integrating metabolic checkpoints with redox biology, ferroptosis emerges as a therapeutic target with vast translational potential.
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