Nickel-Catalyzed Asymmetric C(sp2)-P Coupling for the Direct Synthesis of the PMOP Atropisomeric Phosphine Ligand
Bendu Pan1, Mingliang Li2, Zhiping Yang1
1Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong999077, China.
Abstract:
An efficient kinetic resolution of binaphthyl triflates is developed via Ni-catalyzed asymmetric C(sp2)-P cross-coupling to access substituted atropisomeric phosphines. Moreover, the phosphine framework showed superior reactivity and enantiocontrol in Pd-catalyzed asymmetric allylic substitution. Mechanistic control experiments revealed that the introduction of a pyridine ring provides both optimal steric hindrance and a secondary coordination site, enabling the successful development of a new class of atropisomeric P,N-bidentate ligands, denoted as PMOP.
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