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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Published on: June 15, 2019

Early Management of Sepsis

Elizabeth S Munroe¹, Ithan D Peltan¹, Hallie C Prescott²

¹Department of Pulmonary and Critical Care Medicine, Intermountain Medical Center, Murray, UT, USA.

Critical Care Clinics

|September 2, 2026

Abstract:

Prompt recognition and appropriate early management of sepsis reduces mortality. There are 2 major goals of early sepsis management, which should be pursued urgently and in parallel-(1) infection control and (2) hemodynamic resuscitation. Treating infection involves timely antimicrobial therapy, and for some infections, source control. Hemodynamic resuscitation should start with a rapid bolus of balanced crystalloid followed by personalized approaches that tailor fluid and vasopressor therapy to evolving patient physiology. In patients who do not improve with initial antibiotic therapy and resuscitation, it is essential to reassess adequacy of infection control and resuscitation.

Keywords:

Antimicrobial therapy IV fluids Resuscitation Sepsis Septic shock Vasopressors

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