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Identification of the Novel HLA-DQA1*01:215 Allele by Next- and Third-Generation Sequencing

Romain Ferru-Clément1, Marion Raguenault1, Diana Ratiarison1

  • 1Laboratoire d'Histocompatibilité et Immunogénétique, Etablissement Français du Sang Nouvelle Aquitaine, Poitiers, France.

HLA
|September 17, 2026
PubMed

Keywords:
HLA‐DQA1*01:215HLAOxford Nanopore Technologiesnovel allelesequencing‐by‐synthesis

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.