Integrating blood vessel organoids makes stem cell-derived islets more competent
Related Experiment Video
Updated: Nov 7, 2026
08:35
In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors
Published on: July 19, 2014
Daniel M Tremmel1, Yonglin Zhu1, Juan M Melero-Martin2
1Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Cell Stem Cell
|November 5, 2026
Abstract:
Wang et al. present an all-stem-cell strategy that vascularizes pancreatic islet organoids by integrating them with blood vessel organoids, enhancing β cell maturation and resilience and reversing diabetes in mice.1 The resulting model offers a platform to study islet-vascular biology in vitro and to advance transplantation therapies.