Not born in the brain: Bone marrow-derived microglia in human aging
Related Experiment Video
Updated: Nov 7, 2026
09:41
Obtaining Human Microglia from Adult Human Brain Tissue
Published on: August 30, 2020
Jeongmin Seo1, Sojung Kim1, Jina Lee1
1Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Cell Stem Cell
|November 5, 2026
Abstract:
In a study recently published in Nature, Belk et al.1 use somatic mutations to demonstrate that bone marrow-derived cells enter the aging human brain and resemble microglia. The aged microglial compartment may therefore have a substantial hematopoietic contribution, and its clonal composition may prove important for stem-cell-based microglial replacement.
