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Collagen heterogeneity in systemic scleroderma and other diseases
Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
|July 1, 1979
Summary
Malignant systemic scleroderma significantly increased collagen type III proportions in tissues like the kidney. This collagen elevation, particularly in the kidneys, critically impaired function, leading to fatal uremia in the patient.
Area of Science:
- Biochemistry
- Pathology
- Nephrology
Background:
- Collagen types I and III are crucial extracellular matrix components.
- Altered collagen proportions are implicated in various fibrotic and inflammatory diseases.
- Systemic scleroderma is characterized by fibrosis affecting multiple organs.