Subcutaneous fat necrosis in pancreatitis

Area of Science:

• Gastroenterology
• Pathology
• Dermatology

Background:

• Acute pancreatitis is a serious condition with diverse clinical manifestations.
• Subcutaneous fat necrosis is an uncommon extrapancreatic complication.

Observation:

• A case is presented where subcutaneous fat necrosis was the initial symptom of acute pancreatitis.
• Associated symptoms included respiratory distress, leukemoid reaction, shock, pleural effusions, and arthritis.

Findings:

• Autopsy revealed pancreatic pseudocyst, serofibrinous peritonitis, pleuritis, and pericarditis.
• Fat necrosis was extensive, found in subcutaneous, pericardial, pleural, mediastinal, mesenteric, retroperitoneal, and pericalyceal tissues.

Implications:

• This case underscores the importance of considering acute pancreatitis in patients presenting with subcutaneous fat necrosis.
• Widespread fat necrosis indicates severe systemic involvement and necessitates prompt, aggressive management.
• Highlights the multifaceted nature of pancreatitis complications beyond the pancreas itself.