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[The geographic distribution of psoriasis]
Summary
Psoriasis vulgaris frequency is increasing globally, particularly in industrialized nations, suggesting environmental factors may trigger genetic predispositions. Further research into human leukocyte antigen (HLA) associations is crucial for understanding this distribution.
Area of Science:
- Dermatology
- Epidemiology
- Genetics
Context:
- Psoriasis vulgaris is a chronic inflammatory skin condition with a complex geographical distribution.
- Recent literature indicates a rising frequency of psoriasis in specific regions like Japan, Korea, Kazakhstan, and East Africa.
- Altered living conditions and industrialization are hypothesized to influence the manifestation of psoriasis genes.
Purpose:
- To describe the geographical distribution of psoriasis vulgaris.
- To explore potential contributing factors, including genetic and environmental influences.
- To investigate associations between psoriasis and human leukocyte antigen (HL-A) systems.
Summary:
- The geographical distribution of psoriasis vulgaris reveals an increasing frequency in several countries, potentially linked to industrialization and altered life conditions.
- Genetic factors are considered, but population differences in psoriasis frequency are unlikely to be solely genetic.
- No correlation was found between psoriasis and climatic factors, but associations with HL-A antigens (HL-A 13 and W 17) were observed.
Impact:
- The observed associations with HL-A antigens may be significant for interpreting the geographical patterns of psoriasis.
- Findings highlight the need for further family-based studies to investigate HL-A specificities in individuals genetically predisposed to psoriasis.
- Understanding these geographical and genetic links can inform future research and potential therapeutic strategies for psoriasis vulgaris.