Function of macrophage prostaglandins in the process of phagocytosis

The role of prostaglandins (PGs) in phagocytosis of sheep erythrocytes (SRC) by mouse spleen adherent cells was examined. A decrease of about 50% in the phagocytosis was observed when macrophages were treated with 5 microgram/ml indomethacin. Concomitant addition of PGs (10(-6) mg/ml), however, prevented the inhibitory effect of indomethacin. It is thus suggested that PGs play an important role in phagocytosis.