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Gonadal function in chronic alcoholic men.

R Lester, D H Van Thiel

    Advances in Experimental Medicine and Biology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Alcoholism causes male feminization through liver disease and direct endocrine effects. Alcohol disrupts hormone production and metabolism, leading to feminizing symptoms in men.

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    Area of Science:

    • Endocrinology
    • Hepatology
    • Men's Health

    Background:

    • Alcoholism impacts millions, with up to 80% of severe alcoholic men exhibiting feminization.
    • Feminization in alcoholic men includes impotence, testicular atrophy, sterility, gynecomastia, and altered body hair.
    • The precise causes of male alcoholic feminization have been historically unclear.

    Purpose of the Study:

    • To investigate the pathogenesis of feminization in male alcoholics.
    • To elucidate the roles of alcohol-induced liver disease and direct endocrine effects.
    • To examine alterations in sex hormone levels and hypothalamic-pituitary function.

    Main Methods:

    • Utilized advanced techniques for sex hormone measurement.
    • Examined the interplay between alcohol, liver function, and endocrine pathways.

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  • Assessed steroidogenesis, testosteronogenesis, and hypothalamic-pituitary function in chronic alcoholics.

    • Main Results:

    • Alcohol-induced liver disease contributes to feminization by allowing peripheral conversion of steroid precursors to estrogens.
    • The diseased liver inadequately clears these estrogenic substances.
    • Alcohol directly impairs testicular steroidogenesis and testosteronogenesis.
    • Chronic alcoholism diminishes hypothalamic-pituitary function, further contributing to feminization.

    Conclusions:

    • Male alcoholic feminization results from both secondary effects of liver disease and primary effects on the endocrine system.
    • Alcohol's impact on hormone metabolism and production are key factors.
    • Understanding these mechanisms is crucial for addressing health consequences in alcoholism.