[Hypothalamo-hypophyseal-adrenal system in the regulation of immunologic processes]

Glucocorticoids are concluded to be modulators of immune reactions capable of changing different parameters of the immune responses. The conclusion is based on investigation of correlations between endogenous glucocorticoids level and intensity of humoral and cell-mediated immune response in different experimental sets. Changes of cyclic nucleotides level in spleen lymphocytes induced by antigen were shown to depend on the intensity of hormonal shifts. The major significance of the intensity of hormonal changes and the sensitivity of cell populations to hormones for the final hormonal influence, is emphasized.