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Glucose intolerance in uremia (A- and B-cell function during conservative and dialytic management
Acta Diabetologica Latina
|September 1, 1977
Summary
Uremic patients exhibit glucose intolerance, mainly due to peripheral insulin resistance, not high glucagon levels. Hemodialysis offers some improvement in glucose disposal but does not fully normalize it.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Disorders
Background:
- Uremia, a condition of kidney failure, is associated with metabolic disturbances.
- Altered glucose metabolism and hormonal regulation are common in patients with chronic kidney disease.
Purpose of the Study:
- To investigate glucose tolerance and insulin/glucagon secretion in uremic patients undergoing conservative and hemodialytic treatments.
- To determine the primary cause of glucose intolerance in uremia.
Main Methods:
- Glucose infusion test performed in fasting uremic patients (conservative and hemodialysis groups) and controls.
- Measurement of plasma insulin and glucagon levels before and after glucose infusion.
Main Results:
- Uremic patients demonstrated glucose intolerance.
- Hemodialysis partially improved glucose disposal but did not normalize it.
- Elevated plasma insulin and glucagon levels were observed in uremic patients compared to controls, with preserved glucagon suppression.
Conclusions:
- Glucose intolerance in uremia is primarily attributed to peripheral insulin resistance.
- Hyperglucagonemia is not the main driver of glucose intolerance in uremic patients.