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High incidence of beta-2-microglobulin containing macromolecular complexes in sarcoidosis sera
Abstract:
In thirteen out of fourteen sarcoidosis patients with elevated serum levels of immune complexes beta-2-microglobulin (beta 2m) was detected in immune complex-enriched fractions prepared by precipitation with 3% polyethylene glycol. Beta-2-microglobulin was also contained in complexes isolated by means of solid-phase Clq. The levels of free beta 2m in sarcoidosis sera did not differ from the concentrations in sera from healthy donors.