[Trophoblastic cryptocarcinoma with mononucleate cells, secreting beta chorionic gonadotropic hormones in seminoma....

In 18 cases of seminoma of the testis correlations were established between beta HCG secretion, as demonstrated by the PAP immunoperoxidase technique, serum radioimmunological assays and clinical course of the disease. Mononucleate beta HCG-producing cells were found side by side with multinucleate syncytiotrophoblastic cells. This information was obtained earlier with the immunohistochemical technique than with radioimmunological assays. The immunoperoxidase technique makes it possible to detect mononucleate beta HCG-positive cell cryptocarcinomas which, when present in stage II seminomas, constitute a very dangerous dysgerminal tumour.