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Related Experiment Videos

[Gonadoliberin. Therapeutic prospects].

R Sitruk-Ware, Y Le Bouc, A Gompel

    Presse Medicale (Paris, France : 1983)
    |March 3, 1984
    PubMed
    Summary

    Long-acting luteinizing hormone-releasing hormone (LH-RH) analogues show therapeutic potential. Paradoxically, agonists inhibit reproductive functions by desensitizing the pituitary, suggesting uses in contraception and hormone-dependent conditions.

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    Andrology·2019

    Area of Science:

    • Endocrinology
    • Reproductive Biology

    Context:

    • Luteinizing hormone-releasing hormone (LH-RH) analogues offer therapeutic possibilities.
    • Biochemical modifications have yielded potent LH-RH antagonists and agonists.

    Purpose:

    • To explore the therapeutic applications of novel LH-RH analogues.
    • To understand the paradoxical inhibitory effects of LH-RH agonists.

    Summary:

    • LH-RH agonists, intended to induce ovulation, paradoxically inhibit reproductive functions by downregulating pituitary LH-RH receptors and causing desensitization.
    • Unlike physiological LH-RH, prolonged analogue activity leads to these inhibitory effects.
    • Human gonads lack specific LH-RH receptors; observed steroid alterations result from initial LH surges induced by agonists.

    Impact:

    • LH-RH antagonists and agonists demonstrate complete gonadotropic inhibition.
    • These analogues show promise for treating hormone-dependent carcinomas, isosexual precocious puberty, and contraception.

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