Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathways of T cell suppression.

F Paraskevas

    Critical Reviews in Immunology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This review examines suppressor cells in immune responses, detailing their induction, function, and control by the MHC. Their role in immunity, tumor growth, and autoimmunity, particularly in lupus models, is discussed.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cytodiagnosis of lymphoid proliferations by fine needle aspiration biopsy. Adjunctive value of flow cytometry.

    Acta cytologica·1999
    Same author

    Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia.

    American journal of hematology·1995
    Same author

    Evidence for a second cell cycle block at G2/M by p53.

    Oncogene·1995
    Same author

    The antiproliferative potency of histamine antagonists correlates with inhibition of binding of [3H]-histamine to novel intracellular receptors (HIC) in microsomal and nuclear fractions of rat liver.

    Agents and actions. Supplements·1991
    Same author

    Histamine as an intracellular messenger.

    Biochemical pharmacology·1990
    Same author

    A role for isotype-specific binding factors in the regulation of IgA- and IgG-specific responses by the anti/contrasuppressor T cell circuit.

    Journal of immunology (Baltimore, Md. : 1950)·1989
    Same journal

    Leveraging Type I Interferons: Exploring Pathogenesis and Therapeutic Strategies in Autoimmune Diseases.

    Critical reviews in immunology·2026
    Same journal

    SLC2A1-Dependent Ketone Metabolism Regulates Tumor Progression and Immunotherapy Efficacy in Lung Adenocarcinoma.

    Critical reviews in immunology·2026
    Same journal

    Knockdown of IGF2BP2 Inhibits THBS1 in Regulating the Progression of Oral Squamous Cell Carcinoma: An Integrative Analysis.

    Critical reviews in immunology·2026
    Same journal

    Plasmodium Phosphatidylinositol 4-Kinase Beta (PI4Kβ): An Emerging Target at the Interface of Parasite Biology and Host Immunity.

    Critical reviews in immunology·2026
    Same journal

    Fusion Gene EPHB4-MET Driven by HOXA9 and Exerted Oncogenic Activity in Non-Small Cell Lung Cancer.

    Critical reviews in immunology·2026
    Same journal

    Secreted Phosphoprotein 1 Represents a Therapeutic Target that Promotes the Progression of Ovarian Cancer by Driving M2 Macrophage Infiltration.

    Critical reviews in immunology·2026
    See all related articles

    Area of Science:

    • Immunology
    • Cell Biology
    • Genetics

    Background:

    • Suppressor cells are crucial components of the immune system, regulating immune responses.
    • Understanding suppressor cell function is vital for comprehending immune homeostasis and disease.
    • Recent advances highlight the role of the Major Histocompatibility Complex (MHC) in suppressor cell regulation.

    Purpose of the Study:

    • To review methods for detecting suppressor cells generated during immune responses.
    • To examine the induction requirements, mechanisms, and functional relationships of suppressor cells.
    • To discuss the implications of suppressor cells in various physiological and pathological conditions.

    Main Methods:

    • Literature review of studies on suppressor cell detection and characterization.

    Related Experiment Videos

  • Analysis of experimental data on suppressor cell induction and function.
  • Examination of genetic control mechanisms, including the role of MHC I regions.

    • Main Results:

    • Suppressor cells are generated during immune responses and their induction is controlled by MHC.
    • These cells interact with other immune subpopulations like helper and cytotoxic T cells.
    • Suppressor cells are implicated in allotypic suppression, tumor growth, and potentially autoimmunity.

    Conclusions:

    • Suppressor cells play a significant role in immune regulation and various disease models.
    • Loss of suppressor cell function is linked to autoimmune disease progression, as seen in lupus models.
    • The precise mechanisms of suppressor cell action and the nature of their soluble mediators require further investigation.