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[Change in the cyclic nucleotide system components in neurogenic myopathies]
Voprosy Meditsinskoi Khimii
|September 1, 1980
Abstract:
Values of Kdiss of the "protein kinase-cAMP" complex were decreased 2-6-fold in muscular tissue of patients with neurogenic myopathies. An increase in affinity of the protein kinase to cAMP correlated with the severity of the disease. Alteration in the cAMP-sGMP ratio, due to decrease in cGMP content, was found in patients with side amyotrophic sclerosis.