The control of phosphate uptake by the isolated renal tubule

An in vitro isolated tubular model is presented which appears to have many characteristics of an active transport system in that Pi accumulation by the preparation is sodium- and temperature-dependent, stimulated by PTH and cAMP and is also conditioned by the metabolic integrity of the tissue. The relationship between the observations made in the dispersed convolutal tubule preparation in the present study and the mechanisms by which PTH affects phosphate transport in isolated perfused tubules and in vivo has not yet been ascertained.