Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pancreatic beta-endorphin-like polypeptides.

J C Houck, C M Chang, C D Kimball

    Pharmacology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A sudden change and recovery in the magnetic environment around a repeating fast radio burst.

    Science (New York, N.Y.)·2026
    Same author

    [Risk factors of delirium after Sun's procedure for acute type A aortic dissection and its influence on patients' prognosis].

    Zhonghua yi xue za zhi·2025
    Same author

    Identification of immunogenic outer membrane vesicle vaccine antigen components using a meningococcal protein microarray.

    Vaccine·2025
    Same author

    A bright burst from FRB 20200120E in a globular cluster of the nearby galaxy M81.

    Nature communications·2024
    Same author

    An Intercomparison Between NPL (India) and NIST (USA) Pressure Standards in the Hydraulic Pressure Region up to 26 MPa.

    Journal of research of the National Institute of Standards and Technology·2023
    Same author

    An Intercomparison of Pressure Standards Between LNE and NBS.

    Journal of research of the National Bureau of Standards (1977)·2021
    Same journal

    Safety and efficacy of Efbemalenograstim alfa for patients at risk for chemotherapy-induced neutropenia: A Systematic review and Meta-analysis.

    Pharmacology·2026
    Same journal

    Retraction Statement.

    Pharmacology·2026
    Same journal

    Antiplatelet Therapy After Endovascular Intracranial Aneurysm Surgery: Comparative Effectiveness and Safety Insights from Systematic Review and Meta-Analysis.

    Pharmacology·2026
    Same journal

    Ciprofol versus Propofol for General Anesthesia Induction in Major Orthopedic Surgery: Efficacy and Safety Analyses Pertaining to Anesthetic Parameters.

    Pharmacology·2026
    Same journal

    Sappanone A targets TFEB to promote lysosomal autophagy and attenuate high glucose-induced myocardial injury.

    Pharmacology·2026
    Same journal

    Tocilizumab Biosimilars Versus Reference Tocilizumab in Rheumatoid Arthritis: A Meta-Analysis of Pharmacokinetic Biosimilarity, Efficacy, Safety, and Immunogenicity.

    Pharmacology·2026
    See all related articles

    Researchers discovered a beta-endorphin-like substance in porcine pancreas extracts. This peptide exhibits analgesic properties and affects mouse behavior, similar to synthetic human beta-endorphin.

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Pharmacology

    Background:

    • Porcine pancreas extracts contain biologically active compounds.
    • Opioid peptides play crucial roles in pain modulation and behavior.

    Purpose of the Study:

    • To identify and characterize opioid-like material in porcine pancreas.
    • To investigate the biological activity of this material.

    Main Methods:

    • Radioimmunoassay for beta-endorphin.
    • Radioligand receptor binding assays using 3H-Naloxone and 3H-enkephalinamide.
    • Size exclusion chromatography (P-10 and G-50).
    • In vivo analgesia and behavioral assays in mice.

    Main Results:

    • Acid extracts of porcine pancreas, but not other tissues, contained material reactive in beta-endorphin radioimmunoassay and competing with radioligands.

    Related Experiment Videos

  • The active material had an approximate molecular weight of 7,000 Da, stable even in 4 M urea.
  • Partially purified fractions induced dose-dependent analgesia and altered mouse behavior in vivo, mimicking synthetic human beta-endorphin.

    • Conclusions:

    • Porcine pancreas contains a beta-endorphin-like substance with opioid activity.
    • This endogenous peptide possesses analgesic and behavioral effects in vivo.
    • Further characterization may reveal novel therapeutic targets for pain management.