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Oral ketoconazole therapy for keratomycosis
American Journal of Ophthalmology
|March 1, 1983
Summary
Oral ketoconazole effectively treated fungal keratitis in two patients, leading to rapid healing and significant vision improvement. This new antifungal agent demonstrated good tolerability with only minor liver enzyme elevations observed.
Area of Science:
- Ophthalmology
- Mycology
- Pharmacology
Background:
- Fungal keratitis poses a significant threat to vision.
- Systemic antifungal therapy is crucial for severe or unresponsive cases.
- Ketoconazole is an azole antifungal agent with broad-spectrum activity.
Observation:
- Two patients with fungal keratitis were treated with oral ketoconazole.
- Dosage administered was 300 mg/day.
- Treatment duration varied between cases.
Findings:
- Corneal ulcer healing and regression initiated within 4-5 days of ketoconazole treatment.
- Clinical signs of infection resolved in 3 and 8 weeks.
- Marked visual acuity improvement was observed in both patients.
- Slight elevations in liver enzymes (SGOT, SGPT) occurred, but no other adverse effects were noted.
Implications:
- Oral ketoconazole shows promise as an effective treatment for fungal keratitis.
- The drug appears to have a favorable safety profile for ocular infections.
- Further research may establish ketoconazole as a valuable therapeutic option in ophthalmology.